Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant
Identifieur interne : 001C54 ( Main/Exploration ); précédent : 001C53; suivant : 001C55Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant
Auteurs : Andrew L. Gilman [États-Unis] ; Amy Serrano [États-Unis] ; John Skelley [États-Unis] ; David Zwick [États-Unis]Source :
- Pediatric Blood & Cancer [ 1545-5009 ] ; 2006-12.
Abstract
We report the clinical course of a patient who developed a Rhizopus infection of his right lung and pleural cavity, 11 months after receiving a T‐cell‐depleted, haploidentical donor peripheral blood stem cell transplant. Thoracotomy was performed to remove the pulmonary lesion, but residual disease in the pleural cavity was noted. Treatment with amphotericin B was complicated by the development of severe renal dysfunction, necessitating alternative antifungal therapy. Treatment was initiated with the investigational triazole posaconazole. Despite concurrent treatment with corticosteroids for graft‐versus‐host disease (GVHD), the patient had a complete response and remains well 4 years later. © 2005 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/pbc.20572
Affiliations:
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